CALL FOR PAPERS CNS Control of Metabolism Arcuate Na ,K -ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons

نویسندگان

  • Hideharu Kurita
  • Kai Y. Xu
  • Yuko Maejima
  • Masanori Nakata
  • Katsuya Dezaki
  • Putra Santoso
  • Yifei Yang
  • Takeshi Arai
  • Darambazar Gantulga
  • Shinji Muroya
  • Alan K. Lefor
  • Masafumi Kakei
  • Eiju Watanabe
  • Toshihiko Yada
چکیده

Hideharu Kurita,* Kai Y. Xu,* Yuko Maejima,* Masanori Nakata,* Katsuya Dezaki, Putra Santoso, Yifei Yang, Takeshi Arai, Darambazar Gantulga, Shinji Muroya, Alan K. Lefor, Masafumi Kakei, Eiju Watanabe, and Toshihiko Yada Department of Physiology, Division of Integrative Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan; Department of Neurosurgery, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan; Department of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, Maryland; Department of Psychiatry, Imamura-bunin Hospital, Kagoshima, Kagoshima, Japan; Department of Surgery, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan; First Department of Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Saitama, Japan; and Department of Developmental Physiology, Division of Adaptation Development, National Institute for Physiological Sciences, Okazaki, Aichi, Japan

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Arcuate Na + , K + - ATPase senses systemic energy states and regulates feeding 1 behavior through glucose - inhibited neurons 2 3

Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding 1 behavior through glucose-inhibited neurons 2 3 Hideharu Kurita, Kai Y. Xu, Yuko Maejima, Masanori Nakata, Katsuya Dezaki, Putra 4 Santoso, Yifei Yang, Takeshi Arai, Darambazar Gantulga, Shinji Muroya, Alan K. Lefor, 5 Masafumi Kakei, Eiju Watanabe, Toshihiko Yada* 6 7 Department of Physiology, Division of Integrative Ph...

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Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons.

Feeding is regulated by perception in the hypothalamus, particularly the first-order arcuate nucleus (ARC) neurons, of the body's energy state. However, the cellular device for converting energy states to the activity of critical neurons in ARC is less defined. We here show that Na(+),K(+)-ATPase (NKA) in ARC senses energy states to regulate feeding. Fasting-induced systemic ghrelin rise and gl...

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Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding

Adiponectin regulates glucose and lipid metabolism, acting against metabolic syndrome and atherosclerosis. Accumulating evidence suggest that adiponectin acts on the brain including hypothalamic arcuate nucleus (ARC), where proopiomelanocortin (POMC) neurons play key roles in feeding regulation. Several studies have examined intracerebroventricular (ICV) injection of adiponectin and reported op...

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Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness

The hypothalamic feeding center plays an important role in energy homeostasis. In the feeding center, whole-body energy signals including hormones and nutrients are sensed, processed, and integrated. As a result, food intake and energy expenditure are regulated. Two types of glucose-sensing neurons exist in the hypothalamic arcuate nucleus (ARC): glucose-excited neurons and glucose-inhibited ne...

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The amount of energy in the body is highly regulated. The hypothalamus is a key neural structure involved in this process, keeping the intake of food in step with the energy expenditure. The main hypothalamic nuclei involved in energetic metabolism regulation are the arcuate, periventricular, dorsomedial and ventromedial that integrates several peripheral signals, such as leptin and adiponectin...

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تاریخ انتشار 2015